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Statistic
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Details for phenotype: ovarian follicle development
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EndoNet ID: ENP00020
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Name
ovarian follicle development
General information
This phenotype is not pathologic
Links to other resources
GO
ovarian follicle development
MeSH term
68006080
Phenotype triggers
normal activity of
angiotensin II type 1 receptor
ui-button
in
ovary
ui-button
Angiotensin II has many roles in the ovary, including folliculogenesis.
[1]
normal activity of
follitropin receptor
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in
granulosa_cell
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Follicle-stimuating hormone has a central role in ovarian folliculogenesis.
[2]
normal activity of
AR
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in
theca_cell
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Studies with AR knockout mice have revealed that AR function is essential for maintaining female fertility, notably through optimizing the conditions for follicular growth, final follicle development and ovulation.
[3]
normal activity of
AR
ui-button
in
granulosa_cell
ui-button
Studies with AR knockout mice have revealed that AR function is essential for maintaining female fertility, notably through optimizing the conditions for follicular growth, final follicle development and ovulation.
[3]
normal activity of
ER-alpha
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in
granulosa_cell
ui-button
Higher ER alpha gene expression in granulosa cells in patients with endometriosis, compared with patients with tubular infertility, implies that endometriosis may cause ovarian dysfunction.
[4]
normal activity of
ER-beta
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in
granulosa_cell
ui-button
ER beta is upregulated in patients with endometriosis. Elevated ER expression might be a leading cause of ovarian dysfunction.
[4]
Reference