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Details for phenotype: regulation of gene expression

EndoNet ID: ENP00022

Name

regulation of gene expression

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68015870

Phenotype triggers

  • normal activity of VDR
    in osteoblast
    • After binding of calcitriol vitamin D receptor regulates gene transcription by binding to vitamin D responsive elements in promotor region of target genes. [1]
  • normal activity of FTS receptor
    in T-lymphocyte
    • In vivo thymulin treatment has effect on the IL-2R expression and on the avian CD4+ and CD8+ T cell populations. [2]
  • normal activity of LXR-alpha
    in fat_cell
    • Expression and ligand activation of LXRα has no significant effect on adipogenesis or lipid accumulation and does not modulate the adipogenic activity of PPARγ. The identification of novel LXR adipocyte target genes in cultured cells and in vivo points to an important role for LXR in the regulation of adipocyte gene expression and adipose tissue function distinct from PPARγ. [3]
Reference