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Statistic
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Details for phenotype: mammary gland development
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EndoNet ID: ENP00031
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Name
mammary gland development
General information
This phenotype is not pathologic
Links to other resources
GO
mammary gland development
Phenotype triggers
normal activity of
progesterone receptor
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in
ovary
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The ovarian steroid hormone progesterone, important for female reproductive functions, including uterine and mammary gland development.
[1]
normal activity of
ER-alpha
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in
mammary_gland
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ER alpha signaling is essential for the development of the adult mammary gland. ER alpha knock out mice lack the development that occurs during pre- and postpubertal stages.
[2]
Due to its ability to stimulate proliferation ER alpha is also a driving force during mammary gland tumorigenesis.
[3]
normal activity of
ER-beta
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in
mammary_gland
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Estrogens are key regulators in mammary development and breast cancer and their effects are mediated by estrogen receptors ER alpha and beta.
[4]
Reference
