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Statistic
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Details for phenotype: negative regulation of immune response
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EndoNet ID: ENP00034
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Name
negative regulation of immune response
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of immune response
MeSH term
68007165
Phenotype triggers
normal activity of
CRF-R1
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in
adrenal_gland
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Hypothalamic secretion of CRH leads to suppression of immune response indirectly via stimulation of glucocorticoid secretion from adrenal glands.
[1]
more activity (high ligand concentration, overexpression) of
glucocorticoid receptor
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in
macrophage
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A recent study exploring the effect of corticosterone on isolated peritoneal macrophages has demonstrated that high corticosterone concentrations suppress macrophage immune functions.
[2]
Responses to high corticosteroid levels are a consequence of GR activation.
[2]
more activity (high ligand concentration, overexpression) of
glucocorticoid receptor
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in
microglial_cell_in_central_nervous_system
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Corticosterone exerts its effects via both corticosteroid receptors in a concentration dependent manner in microglial cells.
[3]
Reference
