Details for phenotype: inhibition of adenylate cyclase activity by G-protein signaling pathway

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EndoNet ID: ENP00074

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Name

inhibition of adenylate cyclase activity by G-protein signaling pathway

General information

This phenotype is not pathologic

Links to other resources

GO	inhibition of adenylate cyclase activity by G-protein signaling pathway
MeSH term	68000262

Phenotype triggers

• normal activity of CaSR ui-button
  in thyroid_gland ui-button
  • G protein-coupled extracellular calcium-sensing receptor inhibits adenylate cyclase through pertussis toxin-sensitive and -insensitive mechanisms. [1]
• normal activity of melatonin 1 receptor ui-button
  in pituitary_gland_of_diencephalon ui-button
  • Inhibition of adenylate cyclase at level of pituitary. [2]
• more activity (high ligand concentration, overexpression) of Lysophosphatidic acid receptor 1 ui-button
  in brain ui-button
  • EDG2 overexpression in a neuronal-like cell exaggerated LPA-stimulated inhibition of adenylate cyclase. [3]

EndoNet at the Institut for Bioinformatics UMG Göttingen