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Statistic
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Details for phenotype: regulation of epithelial cell proliferation
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EndoNet ID: ENP00078
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Name
regulation of epithelial cell proliferation
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of epithelial cell proliferation
MeSH term
68049109
Phenotype triggers
normal activity of
GRP-R
ui-button
in
colon
ui-button
Bombesin causes a significant growth in both the atrophic gut mucosa of rats fed an elemental diet and the injured mucosa of rats. This suggests a possible protective role for bombesin in the maintenance of gut mucosal structure after an injury that results in either atrophy or mucosal disruption.
[1]
In adult rats, bombesin stimulates the proliferation of the colon.
[2]
normal activity of
GRP-R
ui-button
in
pancreas
ui-button
Low doses of bombesin act directly at the acinar cell or through release of non-CCK growth factors whereas high doses of bombesin act in part through CCK release.
[3]
Bombesin stimulates the growth of normal pancreas
[1]
Reference
