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Statistic
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Details for phenotype: antiapoptotic effect
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EndoNet ID: ENP00095
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Name
antiapoptotic effect
General information
This phenotype is not pathologic
Links to other resources
GO
anti-apoptosis
Phenotype triggers
normal activity of
MC1R
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in
melanocyte
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The antiapoptotic effect of alpha-MSH was linked to reduction in cyclopyrimidine dimers, the major UV-induced DNA photoproduct. The antiapoptotic effects of alpha-MSH and the reduction in UVB-induced cyclopyrimidine dimers were not observed in melanocytes expressing loss-of function mutation of MC-1R.
[1]
normal activity of
ER-alpha
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in
osteoblast
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The membrane localization of ER alpha and its interaction with caveolin-1 are required for stretching-induced external signal-regulated kinases (ERKs) activation and anti-apoptosis in osteocytes and osteoblasts.
[2]
Reference
