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Statistic
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Details for phenotype: axon guidance
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EndoNet ID: ENP00106
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Name
axon guidance
General information
This phenotype is not pathologic
Links to other resources
GO
axon guidance
MeSH term
68002465
Phenotype triggers
normal activity of
PLXNB1
ui-button
in
brain
ui-button
Binding of CD100/Sema4D to plexin-B1 (plexin-B1 associates with active Rac) leads to subsequent RhoA activation, this is responsible for CD100/Sema4D-induced growth cone collapse and neurite retraction, demonstrating a requirement for Rho guanine nuclear exchange factors (RhoGEFs) and RhoA activation in CD100/Sema4D-mediated cytoskeletal changes.
[1]
normal activity of
PLXNB1
ui-button
in
hippocampus
ui-button
CD100/Sema4D induced growth cone collapse in hippocampal neurons.
[2]
CD100/Sema4D-Plexin-B1 interactions help to guide developing neuronal cells.
[3]
normal activity of
neuropilin 1
ui-button
in
brain
ui-button
Semaphorin 3a is a chemorepellent with multiple guidance functions, including axon pathfinding.
[4]
normal activity of
neuropilin-2
ui-button
in
neuron
ui-button
nitially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis
[5]
Reference