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Statistic
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Details for phenotype: positive regulation of cell growth
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EndoNet ID: ENP00107
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Name
positive regulation of cell growth
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of cell growth
Phenotype triggers
normal activity of
hepatocyte growth factor receptor
ui-button
in
continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
ui-button
In epithelial cells, plexin-B1 forms a functional receptor complex with Met (the scatter factor-1/hepatocyte growth factor receptor).
[1]
Activation of Met through plexin-B1 requires the extracellular domains of both receptors. The phosphorylation of the plexin-B1/Met complex induced by CD100/Sema4D, which is significantly increased when both CD100/Sema4D and the Met ligand scatter factor-1 are present, is crucial for epithelial cell invasive growth.
[2]
normal activity of
hepatocyte growth factor receptor
ui-button
in
epithelial_cell
ui-button
CD100/Sema4D, as well as scatter factor, triggers invasive growth - this phenomenon is a complex program including cell-cell-dissociation and anchorage-independent growth.
[1]
normal activity of
G-protein coupled receptor 4
ui-button
in
keratinocyte
ui-button
A strong mitogenic effect of SPC was observed in a large number of cell types, such as human keratinocytes.
[3]
Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth.
[4]
normal activity of
G-protein coupled receptor 4
ui-button
in
smooth_muscle_cell
ui-button
A strong mitogenic effect of SPC was observed in a large number of cell types, such as vascular smooth muscle cells.
[5]
Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth.
[6]
normal activity of
G-protein coupled receptor 4
ui-button
in
continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
ui-button
A strong mitogenic effect of SPC was observed in a large number of cell types, such as endothelial cells from different vascular beds.
[7]
Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth.
[4]
Reference