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Details for phenotype: positive regulation of cell growth

EndoNet ID: ENP00107

Name

positive regulation of cell growth

General information

This phenotype is not pathologic

Links to other resources

GO

Phenotype triggers

  • normal activity of hepatocyte growth factor receptor
    in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
    • In epithelial cells, plexin-B1 forms a functional receptor complex with Met (the scatter factor-1/hepatocyte growth factor receptor). [1]
    • Activation of Met through plexin-B1 requires the extracellular domains of both receptors. The phosphorylation of the plexin-B1/Met complex induced by CD100/Sema4D, which is significantly increased when both CD100/Sema4D and the Met ligand scatter factor-1 are present, is crucial for epithelial cell invasive growth. [2]
  • normal activity of hepatocyte growth factor receptor
    in epithelial_cell
    • CD100/Sema4D, as well as scatter factor, triggers invasive growth - this phenomenon is a complex program including cell-cell-dissociation and anchorage-independent growth. [1]
  • normal activity of G-protein coupled receptor 4
    in keratinocyte
    • A strong mitogenic effect of SPC was observed in a large number of cell types, such as human keratinocytes. [3]
    • Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth. [4]
  • normal activity of G-protein coupled receptor 4
    in smooth_muscle_cell
    • A strong mitogenic effect of SPC was observed in a large number of cell types, such as vascular smooth muscle cells. [5]
    • Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth. [6]
  • normal activity of G-protein coupled receptor 4
    in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
    • A strong mitogenic effect of SPC was observed in a large number of cell types, such as endothelial cells from different vascular beds. [7]
    • Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth. [4]
Reference