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Details for phenotype: monocyte activation

EndoNet ID: ENP00113

Name

monocyte activation

General information

This phenotype is not pathologic

Links to other resources

GO

Phenotype triggers

  • no activity (knock out experiment or RNAi) of CD72
    in B-lymphocyte
    • CD100/Sema4D induces immune response through CD72, it appears to play a role in monocyte activation. [1]
    • The negative regulator CD100/Sema4D regulates B cell response through shutting off CD72-mediated negative signaling. [2]
  • TLR1
    in monocyte
    • We provide evidence that hBD-3 activates cells in a TLR1- and TLR2-dependent manner. [3]
    • hBD-3 induces activation of monocytes and mDCs, but not pDCs or B cells, is consistent with the expected pattern of TLR2 and TLR1 expression on these cells. [3]
  • TLR2
    in monocyte
    • We provide evidence that hBD-3 activates cells in a TLR1- and TLR2-dependent manner. [3]
    • hBD-3 induces activation of monocytes and mDCs, but not pDCs or B cells, is consistent with the expected pattern of TLR2 and TLR1 expression on these cells. [3]
  • FPRL1
    in monocyte
    • Recently, we found that a G-protein-coupled, seven-transmembrane receptor, FPRL1, mediates the migration and activation of monocytes and microglia induced by Aβ42. [4]
Reference