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Statistic
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Details for phenotype: glomerulogenesis
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EndoNet ID: ENP00120
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Name
glomerulogenesis
General information
This phenotype is not pathologic
Links to other resources
GO
glomerular basement membrane development
glomerulus development
Phenotype triggers
normal activity of
Integrin alpha-3
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in
continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
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Together, podocytes and endothelial cells synthesize the glomerular basement membrane (GBM) and assemble the tri-layered glomerular filtration barrier. Major GBM components, such as laminin alpha5, form a structural framework for glomerular development, and both laminin alpha5 and its receptor alpha3 integrin are required for glomerulogenesis.
[1]
Reference
