Details for phenotype: induction of podocyte apoptosis

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EndoNet ID: ENP00125

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Name

induction of podocyte apoptosis

General information

This phenotype is not pathologic

Links to other resources

GO	glomerular visceral epithelial cell development

Phenotype triggers

• normal activity of neuropilin 1 ui-button
  in glomerulus ui-button
  • In cultured podocytes, recombinant Sema3a downregulates podocin expression, decreases the interaction between slit diaphragm proteins podocin, nephrin and CD2AP and induces podocyte apoptosis through inhibition of the phosphorylation of AKT. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen