Details for phenotype: podocyte differentiation

• Top
• General information
• Triggers
• Toolbox
  Click to access the toolbox

• Top
• General information
• Triggers
• Toolbox
  Click to access the toolbox

EndoNet ID: ENP00134

Add to network

Name

podocyte differentiation

General information

This phenotype is not pathologic

Links to other resources

Phenotype triggers

• normal activity of neuropilin 1 ui-button
  in kidney ui-button
  • Downregulation of WT1 and nephrin by Sema3a overexpression, and downregulation of PAX2 in Sema3a-/- mice, suggest that Sema3a might function as a modifier of PAX2 and WT1 signaling during podocyte differentiation. Thus, Sema3a may act as a negative regulator of podocyte differentiation pathways by inducing downregulation of WT1 and nephrin. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen