Status
Please wait ...
EndoNet
The information resource about the endocrine network in human.
Search
Search a component
Browse
Browse pathways
Browse hormones
Browse hormones functions
Browse hormone classification
Browse receptors
Network
Load network
Path analysis
Process network
Help
Help
Statistic
About
Details for phenotype: negative regulation of insulin receptor signaling pathway
Top
General information
Triggers
Toolbox
Click to access the toolbox
Top
General information
Triggers
Toolbox
Click to access the toolbox
EndoNet ID: ENP00155
Add to network
Name
negative regulation of insulin receptor signaling pathway
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of insulin receptor signaling pathway
MeSH term
68011972
Phenotype triggers
normal activity of
leptin receptor
ui-button
in
adipose_tissue
ui-button
Leptin inhibits insulin receptor signaling in cultured cells.
[1]
normal activity of
TNFR1
ui-button
in
adipose_tissue
ui-button
TNF-alpha inhibits insulin receptor signaling in cultured cells.
[1]
TNF-α inhibits insulin signaling via stimulation of p55 TNFR and sphingomyelinase activity, which results in the production of an inhibitory form of insulin receptor substrate-1 .
[2]
normal activity of
leptin receptor
ui-button
in
hepatocyte
ui-button
Exposure of hepatic cells to leptin, at concentrations comparable with those present in obese individuals, caused attenuation of several insulin-induced activities, including tyrosine phosphorylation of the insulin receptor substrate-1 (IRS-1), association of the adapter molecule growth factor receptor-bound protein 2 with IRS-1, and down-regulation of gluconeogenesis. In contrast, leptin increased the activity of IRS-1-associated phosphatidylinositol 3-kinase. These in vitro studies raise the possibility that leptin modulates insulin activities in obese individuals.
[3]
Reference