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Statistic
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Details for phenotype: promotion of positive energy balance
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EndoNet ID: ENP00169
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Name
promotion of positive energy balance
General information
This phenotype is not pathologic
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Phenotype triggers
normal activity of
melanocortin-4 receptor
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in
paraventricular_nucleus_of_hypothalamus
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A component of the melanocortin system within the arcuate nucleus of hypothalamus consists of a neuronal population that produces proopiomelanocortin (POMC)-derived peptides, such as alpha-melanocyte stimulating hormone, and cocaine- and amphetamine-regulated transcript (CART) peptides, which promote positive energy balance.
[1]
In the PVN, the peptides derived from the breakdown of POMC (mainly alpha-MSH)are endogeneous agonists of MC4R.
[2]
Reference
