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Details for phenotype: multicellular organismal water homeostasis

EndoNet ID: ENP00180

Name

multicellular organismal water homeostasis

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68014882

Phenotype triggers

  • normal activity of PRLR
    in kidney
    • PRL is clearly involved in water and electrolyte balance in almost all classes of vertebrates, PRLRs are present in kidney, as well as other tissues involved in salt balance. [1]
  • normal activity of PRLR
    in digestive_system
    • increased water and salt absorption in intestine [2]
    • Duodenum: Na+ and Ca2+ [3]
    • Jejunum: Na+, K+, Ca2+ [4]
    • Ileum: Na+, Cl-, K+, Ca2+ [5]
    • Colon: Na+ and Cl- [6]
  • normal activity of PRLR
    in placenta
    • PRL induces a redution in fluid volume in the amnion. [7]
  • normal activity of mineralcorticoid receptor
    in epithelial_cell
    • The classical effects of MR signalling are in epithelial tissues where activation promotes sodium reabsorption and potassium secretion, and is therefore crucial for salt and water retention. [8]
  • normal activity of TrpV4-A
    in dorsal_root_ganglion
    • Blockers of TRPV4 Attenuate the Hypotonic Stimulus-Induced [Ca2+]i Increase in Nociceptors, this suppoprt the involvement of TRPV4 in nociceptor osmosensitivity.
    • TRPV4 is a transducer of osmotic stimulation in primary afferent nociceptive nerve fibers, and a transducer involved in inflammatory pain.
Reference