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Statistic
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Details for phenotype: multicellular organismal water homeostasis
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EndoNet ID: ENP00180
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Name
multicellular organismal water homeostasis
General information
This phenotype is not pathologic
Links to other resources
GO
multicellular organismal water homeostasis
MeSH term
68014882
Phenotype triggers
normal activity of
PRLR
ui-button
in
kidney
ui-button
PRL is clearly involved in water and electrolyte balance in almost all classes of vertebrates, PRLRs are present in kidney, as well as other tissues involved in salt balance.
[1]
normal activity of
PRLR
ui-button
in
digestive_system
ui-button
increased water and salt absorption in intestine
[2]
Duodenum: Na+ and Ca2+
[3]
Jejunum: Na+, K+, Ca2+
[4]
Ileum: Na+, Cl-, K+, Ca2+
[5]
Colon: Na+ and Cl-
[6]
normal activity of
PRLR
ui-button
in
placenta
ui-button
PRL induces a redution in fluid volume in the amnion.
[7]
normal activity of
mineralcorticoid receptor
ui-button
in
epithelial_cell
ui-button
The classical effects of MR signalling are in epithelial tissues where activation promotes sodium reabsorption and potassium secretion, and is therefore crucial for salt and water retention.
[8]
normal activity of
TrpV4-A
ui-button
in
dorsal_root_ganglion
ui-button
Blockers of TRPV4 Attenuate the Hypotonic Stimulus-Induced [Ca2+]i Increase in Nociceptors, this suppoprt the involvement of TRPV4 in nociceptor osmosensitivity.
TRPV4 is a transducer of osmotic stimulation in primary afferent nociceptive nerve fibers, and a transducer involved in inflammatory pain.
Reference