Details for phenotype: reduction of cytokine gene expression

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EndoNet ID: ENP00191

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Name

reduction of cytokine gene expression

General information

This phenotype is not pathologic

Links to other resources

GO	negative regulation of cytokine biosynthetic process

Phenotype triggers

• normal activity of PRLR ui-button
  in Kupffer_cell_stellate_cell_of_liver ui-button
  • Haemorrhage markedly increases the level of mRNA for IL-1 beta, IL-6, TGF-beta and TNF-beta in Kupffer cells. In vivo PRL treatment significantly decreases the cytokine gene expression in Kupffer cells following haemorrhage. Thus, PRL may be useful in blunting the systemic inflammatory response associated with cell and organ depression following shock. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen