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Details for phenotype: positive regulation of smooth muscle proliferation

EndoNet ID: ENP00193

Name

positive regulation of smooth muscle proliferation

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68049109

Phenotype triggers

  • normal activity of CCK-2
    in enterochromaffin_like_cell
  • normal activity of PRLR
    in smooth_muscle_cell
    • Prolactin induces proliferation of vascular smooth muscle cells through a protein kinase C-dependent mechanism. [1]
  • more activity (high ligand concentration, overexpression) of Lysophosphatidic acid receptor 1
    in smooth_muscle_cell
    • Overexpression of S1PR1 in VSMCs enhances mitogenic responses to S1P. [2]
  • normal activity of TNFRSF12A
    in smooth_muscle_cell
    • TNFSF12 induces proliferation of human aortic smooth muscle cells in vitro and acts as a potent inducer of angiogenesis. [3]
  • normal activity of TNFRSF12A
    in smooth_muscle
    • TNFSF12 induces proliferation of human aortic smooth muscle cells in vitro. [3]
  • normal activity of TNFRSF12A
    in heart
    • TNFSF12 induces proliferation of human aortic smooth muscle cells in vitro. [3]
Reference