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Details for phenotype: regulation of leukocyte migration

EndoNet ID: ENP00228

Name

regulation of leukocyte migration

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68002465

Phenotype triggers

  • normal activity of Sphingosine 1-phosphate receptor 4
    in lymphocyte
    • S1PR4 is the receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. [1]
  • normal activity of Sphingosine 1-phosphate receptor 4
    in dendritic_cell_in_lymphoid_tissues
    • S1PR4 is dominantly expressed on mouse dendritic cells and has an important role in DC trafficking. [2]
  • normal activity of Sphingosine 1-phosphate receptor 1
    in B-lymphocyte
    • During an antibody response, S1PR1 on IgG-secreting plasma cells is required for the cells to move from the spleen into the blood and, ultimately, to the bone marrow. [3]
    • A similar scenario seems to exist for IgA-producing B cells, which require S1P signalling to migrate out of Peyers patches. [4]
    • In addition to homing to and egress from lymphoid tissues, S1P signalling functions to properly compartmentalize immune cells in lymphoid tissues. An example is the localization and movement of marginal-zone B cells in the spleen, which depend on their expression of S1PR1. [5]
    • S1P signalling has a role in both the homing of immune cells to lymphoid organs, and in controlling their egress into blood and lymph. [6]
    • S1PR1 is decisive for B- cell egress from lymph nodes. [7]
  • normal activity of Sphingosine 1-phosphate receptor 1
    in T-lymphocyte
    • S1P signalling has a role in both the homing of immune cells to lymphoid organs, and in controlling their egress into blood and lymph. [6]
    • S1PR1 is decisive for T-cell egress from lymph nodes. [8]
  • normal activity of Sphingosine 1-phosphate receptor 1
    in immune_system
    • S1P signalling has a role in both the homing of immune cells to lymphoid organs, and in controlling their egress into blood and lymph. [6]
    • S1PR1 is decisive for the exit of mature thymocytes — both conventional T cells and natural killer T (NKT) cells — from the thymus. [8]
  • normal activity of Sphingosine 1-phosphate receptor 1
    in lymphocyte
    • Lymphocytes that lack S1PR1 expression cannot egress from lymph nodes and thymus, and lymphocytes with decreased receptor expression levels have a corresponding decreased rate of egress. [7]
  • Duffy
    in endothelial_cell
    • Duffy, expressed in endothelial cells, is a regulator of induced leukocyte trafficking [9]
Reference