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Statistic
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Details for phenotype: regulation of leukocyte migration
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EndoNet ID: ENP00228
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Name
regulation of leukocyte migration
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of leukocyte migration
MeSH term
68002465
Phenotype triggers
normal activity of
Sphingosine 1-phosphate receptor 4
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in
lymphocyte
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S1PR4 is the receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
[1]
normal activity of
Sphingosine 1-phosphate receptor 4
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in
dendritic_cell_in_lymphoid_tissues
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S1PR4 is dominantly expressed on mouse dendritic cells and has an important role in DC trafficking.
[2]
normal activity of
Sphingosine 1-phosphate receptor 1
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in
B-lymphocyte
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During an antibody response, S1PR1 on IgG-secreting plasma cells is required for the cells to move from the spleen into the blood and, ultimately, to the bone marrow.
[3]
A similar scenario seems to exist for IgA-producing B cells, which require S1P signalling to migrate out of Peyers patches.
[4]
In addition to homing to and egress from lymphoid tissues, S1P signalling functions to properly compartmentalize immune cells in lymphoid tissues. An example is the localization and movement of marginal-zone B cells in the spleen, which depend on their expression of S1PR1.
[5]
S1P signalling has a role in both the homing of immune cells to lymphoid organs, and in controlling their egress into blood and lymph.
[6]
S1PR1 is decisive for B- cell egress from lymph nodes.
[7]
normal activity of
Sphingosine 1-phosphate receptor 1
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in
T-lymphocyte
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S1P signalling has a role in both the homing of immune cells to lymphoid organs, and in controlling their egress into blood and lymph.
[6]
S1PR1 is decisive for T-cell egress from lymph nodes.
[8]
normal activity of
Sphingosine 1-phosphate receptor 1
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in
immune_system
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S1P signalling has a role in both the homing of immune cells to lymphoid organs, and in controlling their egress into blood and lymph.
[6]
S1PR1 is decisive for the exit of mature thymocytes — both conventional T cells and natural killer T (NKT) cells — from the thymus.
[8]
normal activity of
Sphingosine 1-phosphate receptor 1
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in
lymphocyte
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Lymphocytes that lack S1PR1 expression cannot egress from lymph nodes and thymus, and lymphocytes with decreased receptor expression levels have a corresponding decreased rate of egress.
[7]
Duffy
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in
endothelial_cell
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Duffy, expressed in endothelial cells, is a regulator of induced leukocyte trafficking
[9]
Reference