Status
Please wait ...
EndoNet
The information resource about the endocrine network in human.
Search
Search a component
Browse
Browse pathways
Browse hormones
Browse hormones functions
Browse hormone classification
Browse receptors
Network
Load network
Path analysis
Process network
Help
Help
Statistic
About
Details for phenotype: astrocyte development
Top
General information
Triggers
Toolbox
Click to access the toolbox
Top
General information
Triggers
Toolbox
Click to access the toolbox
EndoNet ID: ENP00229
Add to network
Name
astrocyte development
General information
This phenotype is not pathologic
Links to other resources
GO
astrocyte development
MeSH term
68001253
Phenotype triggers
normal activity of
Sphingosine 1-phosphate receptor 5
ui-button
in
brain
ui-button
S1PR5 is the receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. S1PR5 may play a regulatory role in the transformation of radial glial cells into astrocytes
[1]
normal activity of
Lysophosphatidic acid receptor 1
ui-button
in
astrocyte
ui-button
A study using LPA1-null astrocytes clearly identified the involvement of this receptor in LPA-mediated astrocyte proliferation.
[2]
Astrocytes primed by LPA increase neuronal differentiation, likely through as yet unidentified soluble factors, and this activity is dependent on activation of LPA1 and in astrocytes.
[3]
Reference
