Details for phenotype: LGL leukemia

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EndoNet ID: ENP00231

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Name

LGL leukemia

General information

This phenotype is not pathologic

Links to other resources

OMIM	151400
Medline Plus	000532
Disease database	2641

Phenotype triggers

• more activity (high ligand concentration, overexpression) of Sphingosine 1-phosphate receptor 5 ui-button
  in lymphocyte ui-button
  • Human sphingosine-1-phosphate receptor 5 gene (S1P5) is overexpressed in large granular lymphocyte (LGL) leukemia. [1]
  • LGL is a lymphopropliferative disorder often associated with autoimmune disease. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen