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Statistic
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Details for phenotype: negative regulation of chemotaxis
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EndoNet ID: ENP00241
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Name
negative regulation of chemotaxis
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of chemotaxis
MeSH term
68002633
Phenotype triggers
more activity (high ligand concentration, overexpression) of
Sphingosine 1-phosphate receptor 1
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in
immune_system
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The effect of S1P on S1PR1-mediated chemotaxis can depend on S1P concentration in vitro; high concentrations of S1P seem to be inhibitory. This inhibitory effect might partly be due to the downregulation of S1PR1 by high concentrations of S1P.
[1]
normal activity of
PACAP-R-1
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in
thymus
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PACAP decreases chemotaxis of thymocytes and splenic lymphocytes through activation of the PKA pathway .
[2]
Reference
