Status
Please wait ...
EndoNet
The information resource about the endocrine network in human.
Search
Search a component
Browse
Browse pathways
Browse hormones
Browse hormones functions
Browse hormone classification
Browse receptors
Network
Load network
Path analysis
Process network
Help
Help
Statistic
About
Details for phenotype: negative regulation of chemotaxis
Top
General information
Triggers
Toolbox
Click to access the toolbox
Top
General information
Triggers
Toolbox
Click to access the toolbox
EndoNet ID: ENP00241
Add to network
Name
negative regulation of chemotaxis
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of chemotaxis
MeSH term
68002633
Phenotype triggers
more activity (high ligand concentration, overexpression) of
Sphingosine 1-phosphate receptor 1
ui-button
in
immune_system
ui-button
The effect of S1P on S1PR1-mediated chemotaxis can depend on S1P concentration in vitro; high concentrations of S1P seem to be inhibitory. This inhibitory effect might partly be due to the downregulation of S1PR1 by high concentrations of S1P.
[1]
normal activity of
PACAP-R-1
ui-button
in
thymus
ui-button
PACAP decreases chemotaxis of thymocytes and splenic lymphocytes through activation of the PKA pathway .
[2]
Reference