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Details for phenotype: dendritic cell chemotaxis

EndoNet ID: ENP00242

Name

dendritic cell chemotaxis

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68002633

Phenotype triggers

  • normal activity of Sphingosine 1-phosphate receptor 3
    in dendritic_cell_in_lymphoid_tissues
    • DCs mainly express S1PR1 when immature but on maturation upregulate S1PR3, which then seems to mediate a chemotatic response to S1P. [1]
  • normal activity of Lysophosphatidic acid receptor 3
    in dendritic_cell_in_lymphoid_tissues
    • LPA3 activation induced chemotaxis of immature, but not mature, DCs. [2]
  • normal activity of Sphingosine 1-phosphate receptor 1
    in dendritic_cell_in_lymphoid_tissues
    • FTY720, a S1P receptor agonist, can severly hamper migration of dendritic cells to the lymph nodes suggesting additional mechanisms underlying the immunosuppressive effects of this spingosine analog. [3]
  • normal activity of Sphingosine 1-phosphate receptor 4
    in dendritic_cell_in_lymphoid_tissues
    • FTY720, a S1P receptor agonist, can severly hamper migration of dendritic cells to the lymph nodes suggesting additional mechanisms underlying the immunosuppressive effects of this spingosine analog. [3]
  • normal activity of Sphingosine 1-phosphate receptor 5
    in dendritic_cell_in_lymphoid_tissues
    • FTY720, a S1P receptor agonist, can severly hamper migration of dendritic cells to the lymph nodes suggesting additional mechanisms underlying the immunosuppressive effects of this spingosine analog. [3]
  • CMKLR1
    in dendritic_cell_in_lymphoid_tissues
    • Human recombinant chemerin promoted in vitro migration of immature DCs whereas no chemotaxis of mature DCs was observed [4]
  • CCR6
    in dendritic_cell_in_lymphoid_tissues
    • β-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6. [5]
    • CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3alpha, a CC chemokine chemotactic for lymphocytes and dendritic cells. [6]
  • CCR7
    in dendritic_cell_in_lymphoid_tissues
    • Migration of DC to lymph nodes is regulated by chemokine receptor CCR7, expressed on mature DC, and the CCR7 ligands CCL19 and CCL21. [7]
Reference