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Statistic
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Details for phenotype: dendritic cell chemotaxis
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EndoNet ID: ENP00242
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Name
dendritic cell chemotaxis
General information
This phenotype is not pathologic
Links to other resources
GO
dendritic cell chemotaxis
MeSH term
68002633
Phenotype triggers
normal activity of
Sphingosine 1-phosphate receptor 3
ui-button
in
dendritic_cell_in_lymphoid_tissues
ui-button
DCs mainly express S1PR1 when immature but on maturation upregulate S1PR3, which then seems to mediate a chemotatic response to S1P.
[1]
normal activity of
Lysophosphatidic acid receptor 3
ui-button
in
dendritic_cell_in_lymphoid_tissues
ui-button
LPA3 activation induced chemotaxis of immature, but not mature, DCs.
[2]
normal activity of
Sphingosine 1-phosphate receptor 1
ui-button
in
dendritic_cell_in_lymphoid_tissues
ui-button
FTY720, a S1P receptor agonist, can severly hamper migration of dendritic cells to the lymph nodes suggesting additional mechanisms underlying the immunosuppressive effects of this spingosine analog.
[3]
normal activity of
Sphingosine 1-phosphate receptor 4
ui-button
in
dendritic_cell_in_lymphoid_tissues
ui-button
FTY720, a S1P receptor agonist, can severly hamper migration of dendritic cells to the lymph nodes suggesting additional mechanisms underlying the immunosuppressive effects of this spingosine analog.
[3]
normal activity of
Sphingosine 1-phosphate receptor 5
ui-button
in
dendritic_cell_in_lymphoid_tissues
ui-button
FTY720, a S1P receptor agonist, can severly hamper migration of dendritic cells to the lymph nodes suggesting additional mechanisms underlying the immunosuppressive effects of this spingosine analog.
[3]
CMKLR1
ui-button
in
dendritic_cell_in_lymphoid_tissues
ui-button
Human recombinant chemerin promoted in vitro migration of immature DCs whereas no chemotaxis of mature DCs was observed
[4]
CCR6
ui-button
in
dendritic_cell_in_lymphoid_tissues
ui-button
β-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.
[5]
CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3alpha, a CC chemokine chemotactic for lymphocytes and dendritic cells.
[6]
CCR7
ui-button
in
dendritic_cell_in_lymphoid_tissues
ui-button
Migration of DC to lymph nodes is regulated by chemokine receptor CCR7, expressed on mature DC, and the CCR7 ligands CCL19 and CCL21.
[7]
Reference