Details for phenotype: positive regulation of leukocyte migration

EndoNet ID: ENP00247

Name

positive regulation of leukocyte migration

This phenotype is not pathologic

GO	positive regulation of leukocyte migration
MeSH term	68002465

normal activity of Sphingosine 1-phosphate receptor 5
in killer_cell
- NK cells rely on S1PR5 to attain a normal tissue distribution, which might also function to promote egress from the bone marrow and lymph nodes into the vascular compartments in response to S1P gradients. [1]
normal activity of Sphingosine 1-phosphate receptor 4
in T-lymphocyte
- S1P has been reported to stimulate migration of T cells that express s1p4 under some conditions. T cell receptor-mediated activation of T cells suppresses expression of s1p4, and it has been reported to eliminate their migration responses to S1P. [2]
normal activity of Sphingosine 1-phosphate receptor 1
in T-lymphocyte
- S1P has been reported to stimulate migration of T cells that express s1p1 under some conditions. T cell receptor-mediated activation of T cells suppresses expression of s1p1, and it has been reported to eliminate their migration responses to S1P. [2]

Reference