Details for phenotype: negative regulation of mast cell degranulation

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EndoNet ID: ENP00258

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Name

negative regulation of mast cell degranulation

General information

This phenotype is not pathologic

Links to other resources

GO	negative regulation of mast cell degranulation
MeSH term	68015550

Phenotype triggers

• no activity (knock out experiment or RNAi) of Sphingosine 1-phosphate receptor 2 ui-button
  in mast_cell ui-button
  • Loss of S1PR2 inhibits high-affinity Fc receptor for IgE-induced mast-cell degranulation (that is, the ability to release granule-stored mast-cell allergic mediators such as histamine). [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen