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Statistic
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Details for phenotype: negative regulation of cytokine production
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EndoNet ID: ENP00261
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Name
negative regulation of cytokine production
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of cytokine production
MeSH term
68016207
Phenotype triggers
normal activity of
Sphingosine 1-phosphate receptor 2
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in
macrophage
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Peritoneal macrophages from low-density lipoprotein-receptor-deficient mice, which are a model for atherosclerosis, that had been treated with FTY720 (FTY720 is a sphingosine analogue that could be phosphorylated by SPHKs to produce a S1PR ligand with potent effects, including S1PR agonism and the downregulation of S1PR expression) had a markedly decreased production of inflammatory tumour-necrosis factor (TNF), TNF receptor (TNFR) and IL-6 in response to LPS.
[1]
normal activity of
Sphingosine 1-phosphate receptor 1
ui-button
in
macrophage
ui-button
Peritoneal macrophages from low-density lipoprotein-receptor-deficient mice, which are a model for atherosclerosis, that had been treated with FTY720 (FTY720 is a sphingosine analogue that could be phosphorylated by SPHKs to produce a S1PR ligand with potent effects, including S1PR agonism and the downregulation of S1PR expression) had a markedly decreased production of inflammatory tumour-necrosis factor (TNF), TNF receptor (TNFR) and IL-6 in response to LPS.
[1]
Reference
