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Statistic
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Details for phenotype: regulation of myelination
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EndoNet ID: ENP00303
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Name
regulation of myelination
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of myelination
MeSH term
68009186
Phenotype triggers
normal activity of
Lysophosphatidic acid receptor 1
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in
Schwann_cell
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Schwann cells (SCs) are the myelinating cells of the peripheral nervous system. SCs express LPA1 and activation of this receptor is known to affect processes associated with myelination.
[1]
normal activity of
Lysophosphatidic acid receptor 2
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in
Schwann_cell
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Schwann cells (SCs) are the myelinating cells of the peripheral nervous system. SCs express LPA2, and activation of this receptor is known to affect processes associated with myelination.
[2]
normal activity of
CaSR
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in
neuron
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Functional CaSRs are expressed in mature oligodendrocytes pointing to a potential role in myelination.
[3]
normal activity of
Sphingosine 1-phosphate receptor 5
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in
oligodendrocyte
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S1P5 expressed by oligodendrocytes might play a role in normal myelination and in demyelinating diseases, such as multiple sclerosis, as its expression is restricted to oligodendrocytes throughout development from immature stages to myelin-forming cells.
[4]
Reference