Details for phenotype: regulation of myelination

EndoNet ID: ENP00303

Name

regulation of myelination

This phenotype is not pathologic

GO	regulation of myelination
MeSH term	68009186

normal activity of Lysophosphatidic acid receptor 1
in Schwann_cell
- Schwann cells (SCs) are the myelinating cells of the peripheral nervous system. SCs express LPA1 and activation of this receptor is known to affect processes associated with myelination. [1]
normal activity of Lysophosphatidic acid receptor 2
in Schwann_cell
- Schwann cells (SCs) are the myelinating cells of the peripheral nervous system. SCs express LPA2, and activation of this receptor is known to affect processes associated with myelination. [2]
normal activity of CaSR
in neuron
- Functional CaSRs are expressed in mature oligodendrocytes pointing to a potential role in myelination. [3]
normal activity of Sphingosine 1-phosphate receptor 5
in oligodendrocyte
- S1P5 expressed by oligodendrocytes might play a role in normal myelination and in demyelinating diseases, such as multiple sclerosis, as its expression is restricted to oligodendrocytes throughout development from immature stages to myelin-forming cells. [4]

Reference