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Statistic
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Details for phenotype: myelin formation in the peripheral nervous system
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EndoNet ID: ENP00307
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Name
myelin formation in the peripheral nervous system
General information
This phenotype is not pathologic
Links to other resources
GO
myelin formation in the peripheral nervous system
MeSH term
68009186
Phenotype triggers
normal activity of
Lysophosphatidic acid receptor 2
ui-button
in
Schwann_cell
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LPA2 signaling appears to be involved in SC function, because its activation results in the upregulation of myelin P0 protein in cultured SCs.
[1]
more activity (high ligand concentration, overexpression) of
Lysophosphatidic acid receptor 2
ui-button
in
Schwann_cell
ui-button
In addition to the role for myelination during developmental stages, evidence indicates a role for LPA signaling in remyelination after injuries such as neuropathic pain and nerve transection where LPA2 is upregulated despite very low levels under basal conditions.
[2]
more activity (high ligand concentration, overexpression) of
Lysophosphatidic acid receptor 1
ui-button
in
Schwann_cell
ui-button
In addition to the role for myelination during developmental stages, evidence indicates a role for LPA signaling in remyelination after injuries such as neuropathic pain and nerve transection where LPA1 is upregulated despite very low levels under basal conditions.
[2]
Reference
