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Statistic
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Details for phenotype: positive regulation of angiogenesis
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EndoNet ID: ENP00312
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Name
positive regulation of angiogenesis
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of angiogenesis
MeSH term
68043925
Phenotype triggers
normal activity of
Lysophosphatidic acid receptor 1
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in
vascularendothelial_cell
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LPA is a mediator in angiogenesis. An initial characterization of knockout mice revealed the presence of frontal cephalic hemorrhages in Lpar1-deficient mice.
[1]
normal activity of
Sphingosine 1-phosphate receptor 1
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in
vascularendothelial_cell
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S1P1 plays a primary role in angiogenesis by its potent activation of Rac, potentially through the intimate interplay with PDGF.
[2]
normal activity of
Sphingosine 1-phosphate receptor 1
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in
smooth_muscle_cell
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S1P receptor edg-1 is essential for cardiovascular development.
[3]
Edg-1 is the first G protein-coupled receptor required for blood vessel formation. In general, sphingolipid signaling is essential during mammalian development.
[3]
normal activity of
ER-beta
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in
lung
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Estradiol therapy reverses the loss of vessels associated with pulmonary hypertension in the lungs in both male and female rats. Estradiol stimulates the growth of new capillaries. The estrogen-effect is likely mediated through ER-beta.
[4]
normal activity of
ER-beta
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in
vascularendothelial_cell
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Estradiol is known to promote angiogenesis in several tissues.
[4]
ER-beta-knockout mice demonstrated abnormal vascular function and hypertension, increased mortality, and aggravation of heart failure.
[5]
normal activity of
Sphingosine 1-phosphate receptor 5
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in
aorta
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S1P promotes endothelial cell growth, thereby promoting blood vessel formation through the interacction with signaling by VEGF.
[6]
Reference