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Details for phenotype: positive regulation of angiogenesis

EndoNet ID: ENP00312

Name

positive regulation of angiogenesis

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68043925

Phenotype triggers

  • normal activity of Lysophosphatidic acid receptor 1
    in vascularendothelial_cell
    • LPA is a mediator in angiogenesis. An initial characterization of knockout mice revealed the presence of frontal cephalic hemorrhages in Lpar1-deficient mice. [1]
  • normal activity of Sphingosine 1-phosphate receptor 1
    in vascularendothelial_cell
    • S1P1 plays a primary role in angiogenesis by its potent activation of Rac, potentially through the intimate interplay with PDGF. [2]
  • normal activity of Sphingosine 1-phosphate receptor 1
    in smooth_muscle_cell
    • S1P receptor edg-1 is essential for cardiovascular development. [3]
    • Edg-1 is the first G protein-coupled receptor required for blood vessel formation. In general, sphingolipid signaling is essential during mammalian development. [3]
  • normal activity of ER-beta
    in lung
    • Estradiol therapy reverses the loss of vessels associated with pulmonary hypertension in the lungs in both male and female rats. Estradiol stimulates the growth of new capillaries. The estrogen-effect is likely mediated through ER-beta. [4]
  • normal activity of ER-beta
    in vascularendothelial_cell
    • Estradiol is known to promote angiogenesis in several tissues. [4]
    • ER-beta-knockout mice demonstrated abnormal vascular function and hypertension, increased mortality, and aggravation of heart failure. [5]
  • normal activity of Sphingosine 1-phosphate receptor 5
    in aorta
    • S1P promotes endothelial cell growth, thereby promoting blood vessel formation through the interacction with signaling by VEGF. [6]
Reference