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Statistic
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Details for phenotype: positive regulation of cell death
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EndoNet ID: ENP00314
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Name
positive regulation of cell death
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of cell death
MeSH term
68016923
Phenotype triggers
normal activity of
Lysophosphatidic acid receptor 1
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in
umbilical_vein_endothelial_cells
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In human umbilical vein endothelial cells (as well as porcine cerebral microvascular cells), LPA was found to induce oncotic cell death via protein nitrosylation. This endothelial cytotoxicity was reproduced in brain explants and retinas in vivo that exhibit diminished vasculature. This was reported to be LPA1 mediated.
[1]
Reference
