Status
Please wait ...
EndoNet
The information resource about the endocrine network in human.
Search
Search a component
Browse
Browse pathways
Browse hormones
Browse hormones functions
Browse hormone classification
Browse receptors
Network
Load network
Path analysis
Process network
Help
Help
Statistic
About
Details for phenotype: negative regulation of smooth muscle cell migration
Top
General information
Triggers
Toolbox
Click to access the toolbox
Top
General information
Triggers
Toolbox
Click to access the toolbox
EndoNet ID: ENP00317
Add to network
Name
negative regulation of smooth muscle cell migration
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of smooth muscle cell migration
MeSH term
68002464
Phenotype triggers
normal activity of
Lysophosphatidic acid receptor 1
ui-button
in
smooth_muscle_cell
ui-button
LPA1 and LPA2 were found to exhibit opposing effects on primary VSMCs derived from knockout mice. The migration of SMCs was increased in Lpar1−/− mice but attenuated in Lpar1−/−/Lpar2−/− mice, thus identifying LPA1 and LPA2 as negative and positive chemotactic mediators, respectively.
[1]
LPA induces the proliferation and migration of vascular smooth muscle cells (VSMCs).
[2]
Reference
