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Details for phenotype: wound healing

EndoNet ID: ENP00318

Name

wound healing

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68014945

Phenotype triggers

  • normal activity of Lysophosphatidic acid receptor 1
    in fibroblast
    • Several lines of evidence suggest that LPA mediates wound healing.
    • LPA induced the closure of wounded endothelial monolayers in vitro. [1]
    • In vivo LPA application promoted repair processes in cutaneous wounds. [2]
    • In vivo LPA application promoted repair processes in intestinal wounds. [3]
    • Migration of fibroblasts into the fibrin wound matrix is an essential step in the wound-healing process in injured tissues, and LPA1 signaling regulates migration of mouse embryonic fibroblasts. [4]
  • normal activity of ER-alpha
    in epidermis
    • ER alpha is expressed in various cell-types and compartments of the penis, including the epidermis of glans penis. [5]
    • Estrogen plays a role in maintaining the glans penis integrity, in part, by facilitating penile healing, possibly via up-regulating levels of VEGF. [6]
  • normal activity of ER-beta
    in epidermis
    • ER beta is expressed in various cell-types and compartments of the penis, including the epidermis of glans penis. [5]
    • Estrogen plays a role in maintaining the glans penis integrity, in part, by facilitating penile healing, possibly via up-regulating levels of VEGF. [6]
  • L-selectin
    in lymphocyte
    • optimal wound healing was found to require the cooperative interactions of all three selectins and ICAM-1 [7]
  • macrophage-stimulating protein receptor
    in keratinocyte
    • The MSP/RON (receptor for MSP) system promotes wound healing. [8]
Reference