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Statistic
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Details for phenotype: wound healing
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EndoNet ID: ENP00318
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Name
wound healing
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of wound healing
wound healing
MeSH term
68014945
Phenotype triggers
normal activity of
Lysophosphatidic acid receptor 1
ui-button
in
fibroblast
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Several lines of evidence suggest that LPA mediates wound healing.
LPA induced the closure of wounded endothelial monolayers in vitro.
[1]
In vivo LPA application promoted repair processes in cutaneous wounds.
[2]
In vivo LPA application promoted repair processes in intestinal wounds.
[3]
Migration of fibroblasts into the fibrin wound matrix is an essential step in the wound-healing process in injured tissues, and LPA1 signaling regulates migration of mouse embryonic fibroblasts.
[4]
normal activity of
ER-alpha
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in
epidermis
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ER alpha is expressed in various cell-types and compartments of the penis, including the epidermis of glans penis.
[5]
Estrogen plays a role in maintaining the glans penis integrity, in part, by facilitating penile healing, possibly via up-regulating levels of VEGF.
[6]
normal activity of
ER-beta
ui-button
in
epidermis
ui-button
ER beta is expressed in various cell-types and compartments of the penis, including the epidermis of glans penis.
[5]
Estrogen plays a role in maintaining the glans penis integrity, in part, by facilitating penile healing, possibly via up-regulating levels of VEGF.
[6]
L-selectin
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in
lymphocyte
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optimal wound healing was found to require the cooperative interactions of all three selectins and ICAM-1
[7]
macrophage-stimulating protein receptor
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in
keratinocyte
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The MSP/RON (receptor for MSP) system promotes wound healing.
[8]
Reference