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Details for phenotype: lymphocyte homeostasis

EndoNet ID: ENP00343

Name

lymphocyte homeostasis

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68055635

Phenotype triggers

  • normal activity of Probable G-protein coupled receptor 132
    in lymphocyte
    • Old G2A-deficient mice (older than 1 year) develop a late-onset autoimmune syndrome, indicating that G2A plays a role in the control of lymphocyte homeostasis. [1]
  • normal activity of Probable G-protein coupled receptor 132
    in spleen
    • Disruption of G2A in mice leads to immunological disorders. The G2A(-/-) mice develop enlarged spleens with abnormal expansion of both T- and B-lymphocytes. [1]
  • normal activity of Probable G-protein coupled receptor 132
    in lymph_node
    • Disruption of G2A in mice leads to immunological disorders. The G2A(-/-) mice develop enlarged lymph nodes with abnormal expansion of both T- and B-lymphocytes. [1]
Reference