Details for phenotype: Systemic lupus erythematosus

EndoNet ID: ENP00367

Name

Systemic lupus erythematosus

This phenotype is pathologic

Systemic lupus erythematosus (SLE) is a clinically heterogeneous multi-system disease which is autoimmune in origin, and characterized by the presence of autoantibodies directed against nuclear antigens. [1]

GO	activation of immune response
OMIM	152700
Medline Plus	000435
MeSH term	D008180
Disease database	12782

Probable G-protein coupled receptor 132
in T-lymphocyte
- Further complexity is introduced by the broad cellular involvement in SLE and the presence of related LPC receptors in multiple immune cell types. [2]
- Several studies suggest that endogenously produced LPC may influence T cell responses and that receptor-mediated signals are involved. [2]
- Increased levels of antibodies against LPC in patients with Systemic Lupus Erythematosus and the development of systemic autoimmune disease in G2A-deficient animals suggest a pathophysiological connection. How the pathology of this disease could relate to this receptor/ligand pair is likely to be complex considering the multiple susceptibility factors involved in SLE. [2]
more activity (high ligand concentration, overexpression) of PRLR
in central_nerve_system_element
- Prolactin has been shown to be increases and to effect a number of autoimmune states, such as systemic lupus erythematosus. [3]

Reference