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Statistic
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Details for phenotype: Systemic lupus erythematosus
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EndoNet ID: ENP00367
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Name
Systemic lupus erythematosus
General information
This phenotype is pathologic
Systemic lupus erythematosus (SLE) is a clinically heterogeneous multi-system disease which is autoimmune in origin, and characterized by the presence of autoantibodies directed against nuclear antigens.
[1]
Links to other resources
GO
activation of immune response
OMIM
152700
Medline Plus
000435
MeSH term
D008180
Disease database
12782
Phenotype triggers
Probable G-protein coupled receptor 132
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in
T-lymphocyte
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Further complexity is introduced by the broad cellular involvement in SLE and the presence of related LPC receptors in multiple immune cell types.
[2]
Several studies suggest that endogenously produced LPC may influence T cell responses and that receptor-mediated signals are involved.
[2]
Increased levels of antibodies against LPC in patients with Systemic Lupus Erythematosus and the development of systemic autoimmune disease in G2A-deficient animals suggest a pathophysiological connection. How the pathology of this disease could relate to this receptor/ligand pair is likely to be complex considering the multiple susceptibility factors involved in SLE.
[2]
more activity (high ligand concentration, overexpression) of
PRLR
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in
central_nerve_system_element
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Prolactin has been shown to be increases and to effect a number of autoimmune states, such as systemic lupus erythematosus.
[3]
Reference