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Statistic
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Details for phenotype: negative regulation of steroid hormone biosynthetic
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EndoNet ID: ENP00398
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Name
negative regulation of steroid hormone biosynthetic
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of steroid hormone biosynthetic process
MeSH term
68013256
Phenotype triggers
normal activity of
BMP receptor type II
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in
adrenal_cortex
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In contrast to BMP-6, it recently could be demonstrated that both BMP-2 and BMP-5 are able to overall suppress forskolin-induced steroidogenesis in NCIh295R cells.
[1]
Specifically, secretion of aldosterone, cortisol, and dehydroepiandrosterone-sulphate, was reduced by BMP-2 and BMP-5 in a dose-dependent manner.
[1]
normal activity of
leptin receptor
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in
granulosa_cell
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Leptin inhibited insulin-induced steroidogenesis by bovine granulosa cells.
[2]
Leptin, at physiologic concentrations, directly affects insulin-induced steroidogenesis of granulosa cells. Normally fluctuating concentrations of leptin in blood may play an important role in communicating the metabolic status of the animal to the reproductive system.
[2]
Leptin significantly suppresses LH-induced estradiol production. This is consistent with an endocrine action of leptin on the human ovary, with possible implications for female reproduction in health and disease.
[3]
High dose of leptin suppressed LH-stimulated estradiol production in human granulosa cells.
[3]
normal activity of
leptin receptor
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in
theca_cell
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Leptin inhibited steroidogenesis by bovine theca cells.
[4]
Leptin, at physiologic concentrations, directly affects steroidogenesis of thecal cells. Normally fluctuating concentrations of leptin in blood may play an important role in communicating the metabolic status of the animal to the reproductive system.
[4]
In cultured theca cells, leptin did not alter androstenedione production, alone or in the presence of LH. Leptin caused a concentration-related inhibition of the IGF-I augmentation of LH-stimulated androstenedione production. Leptin can directly inhibit IGF-I action in ovarian theca at concentrations commonly present in obese women.
[5]
Reference