Details for phenotype: positive regulation of insulin-like growth factor receptor signaling pathway

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EndoNet ID: ENP00411

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Name

positive regulation of insulin-like growth factor receptor signaling pathway

General information

This phenotype is not pathologic

Links to other resources

GO	positive regulation of insulin-like growth factor receptor signaling pathway
MeSH term	68017526

Phenotype triggers

• normal activity of PRLR ui-button
  in prostate ui-button
  • Prolactin has been reported to stimulate the level of IGF-I and IGF-I receptor in the prostate. [1]
  • PRL and GH are involved in regulating AR synthesis, at least partially by direct action on the organ. In this context IGF-I appears as a paracrine factor playing a role in epithelium/stroma interactions during prostatic development. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen