Details for phenotype: experimental allergic encephalomyelitis

EndoNet ID: ENP00448

Name

experimental allergic encephalomyelitis

This phenotype is pathologic

Experimental Allergic Encephalomyelitis is an animal model of brain inflammation charaterized by an inflammatory demyelination of the central nervous system. [1]

GO	regulation of inflammatory response
MeSH term	D004679

more activity (high ligand concentration, overexpression) of PRLR
in central_nerve_system_element
- Prolactin has been shown to be increases and to effect a number of autoimmune states, such as acute experimental allergic encephalomyelitis. [1]
- Prolactin levels are elevated after immunization and before the onset of experimental allergic encephalomyelitis, bromocriptine inhibits both prolactin secretion and the severity of acute experimental allergic encephalomyelitis, and inhibition is also present when treatment is begun after sensitization, suggesting an effect of prolactin on the effector limb of the immune response during experimental allergic encephalomyelitis. [1]

Reference