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The information resource about the endocrine network in human.
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Statistic
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Details for phenotype: regulation of glucose homeostasis
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EndoNet ID: ENP00455
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Name
regulation of glucose homeostasis
General information
This phenotype is not pathologic
Links to other resources
GO
glucose homeostasis
MeSH term
68050260
Phenotype triggers
normal activity of
leptin receptor
ui-button
in
adipose_tissue
ui-button
The ability of leptin to regulate insulin secretion from the pancreatic beta cells might contribute to the abnormalities in glucose homeostasis in obesity .
[1]
normal activity of
TNFR1
ui-button
in
adipose_tissue
ui-button
The ability of TNF-alpha to regulate insulin secretion from the pancreatic beta cells might contribute to the abnormalities in glucose homeostasis in obesity .
[1]
normal activity of
GLP-1R
ui-button
in
beta_cell_of_islet_of_Langerhans
ui-button
Upon secretion, GLP-1 acts on a small selection of tissues to regulate glucose homeostasis.
[2]
When administered to type 2 diabetic subjects, GLP-1 normalizes blood glucose levels, increases circulating insulin, and diminishes glucagon secretion.
[3]
normal activity of
PPARgamma1
ui-button
in
adipose_tissue
ui-button
PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs.
[4]
normal activity of
PPARgamma1
ui-button
in
heart
ui-button
PPAR-gamma is expressed in the heart, one tissue where most of the insulin-stimulated glucose uptake occurs.
[4]
normal activity of
PPAR-gamma1
ui-button
in
fat_cell
ui-button
PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs.
[4]
normal activity of
PPAR-gamma2
ui-button
in
heart
ui-button
PPAR-gamma is expressed in the heart, one tissue where most of the insulin-stimulated glucose uptake occurs.
[4]
normal activity of
PPAR-gamma2
ui-button
in
fat_cell
ui-button
PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs.
[4]
Reference