Status
Please wait ...

Details for phenotype: regulation of glucose homeostasis

EndoNet ID: ENP00455

Name

regulation of glucose homeostasis

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68050260

Phenotype triggers

  • normal activity of leptin receptor
    in adipose_tissue
    • The ability of leptin to regulate insulin secretion from the pancreatic beta cells might contribute to the abnormalities in glucose homeostasis in obesity . [1]
  • normal activity of TNFR1
    in adipose_tissue
    • The ability of TNF-alpha to regulate insulin secretion from the pancreatic beta cells might contribute to the abnormalities in glucose homeostasis in obesity . [1]
  • normal activity of GLP-1R
    in beta_cell_of_islet_of_Langerhans
    • Upon secretion, GLP-1 acts on a small selection of tissues to regulate glucose homeostasis. [2]
    • When administered to type 2 diabetic subjects, GLP-1 normalizes blood glucose levels, increases circulating insulin, and diminishes glucagon secretion. [3]
  • normal activity of PPARgamma1
    in adipose_tissue
    • PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]
  • normal activity of PPARgamma1
    in heart
    • PPAR-gamma is expressed in the heart, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]
  • normal activity of PPAR-gamma1
    in fat_cell
    • PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]
  • normal activity of PPAR-gamma2
    in heart
    • PPAR-gamma is expressed in the heart, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]
  • normal activity of PPAR-gamma2
    in fat_cell
    • PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]
Reference