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Statistic
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Details for phenotype: pancreatc B cell differentiation
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EndoNet ID: ENP00457
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Name
pancreatc B cell differentiation
General information
This phenotype is not pathologic
Links to other resources
GO
pancreatic B cell differentiation
MeSH term
68002454
Phenotype triggers
normal activity of
GLP-1R
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in
beta_cell_of_islet_of_Langerhans
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The biologic actions of GLP-1 in the β-cell include restoration of glucose competence in glucose-resistant β-cells.
[1]
The biologic actions of GLP-1 in the β-cell include stimulation of β-cell mass expansion.
[2]
GLP-1 acts as a growth factor for the β-cell both in experimental animal models and cultured β-cells by stimulating proliferation, survival and differentiation.
[2]
GLP-1 has been initially shown to promote β-cell replication in vitro as well as in vivo in a partial pancreatectomy rat model of type 2 diabetes.
[3]
Reference
