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Statistic
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Details for phenotype: positive regulation of anti-apoptosis
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EndoNet ID: ENP00459
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Name
positive regulation of anti-apoptosis
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of anti-apoptosis
MeSH term
68051017
Phenotype triggers
normal activity of
GLP-1R
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in
beta_cell_of_islet_of_Langerhans
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The action of GLP-1 on cell proliferation is complemented by its effect on cell survival. Indeed, GLP-1 and its analogs exhibited anti-apoptotic properties in several rodent models.
[1]
Mice with disruption of the Glp1r gene exhibit enhanced β-cell death and more severe hyperglycaemia following administration of the β-cell toxin, steptozotocin .
[2]
Reference
