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Statistic
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Details for phenotype: production of molecular mediator involved in inflammatory
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EndoNet ID: ENP00471
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Name
production of molecular mediator involved in inflammatory
General information
This phenotype is not pathologic
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GO
production of molecular mediator involved in inflammatory response
MeSH term
68007249
Phenotype triggers
more activity (high ligand concentration, overexpression) of
mineralcorticoid receptor
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in
macrophage
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Inflammation may be a key mechanism translating MR signalling into cardiac and vascular remodelling.
[1]
Mineralocorticoid/salt-induced pathology is characterised by an early vascular inflammatory response with elevated cardiac expression of inflammatory mediators such as monocytes/macrophages, MCP-1 and adhesion molecules (ICAM-1 and VCAM-1), prior to the onset of collagen deposition.
[2]
mineralocorticoid/salt treatment is also associated with increased monocyte/macrophage infiltration and expression of inflammatory markers such as osteopontin, MCP-1, IL-6 and IL-1β in the kidney.
[3]
MR antagonism prevents inflammation-induced peritoneal fibrosis and reduces macrophage infiltration and expression of MCP-1, TGF-β, PAI-1 and Sgk-1.
[4]
Reference