Details for phenotype: Primary Hyperaldosteronism

EndoNet ID: ENP00481

Name

Primary Hyperaldosteronism

This phenotype is pathologic

Primary aldosteronism implies an excessive organ damage to the heart, vessels and kidney, which translates into an excess of cardiovascular events. [1]

GO	regulation of aldosterone biosynthetic process
Medline Plus	000330
MeSH term	D006929
Disease database	3073

more activity (high ligand concentration, overexpression) of mineralcorticoid receptor
in kidney
- Primary aldosteronism, the most common form of endocrine hypertension is characterized by autonomous aldosterone production by the adrenal cortex (unilateral disease caused by aldosterone-producing adenoma and less frequently by unilateral adrenal hyperplasia; bilateral disease caused by idiopathic adrenal hyperplasia) resulting in hypertension with suppressed plasma renin, and, less frequently, in hypokalemia. [1]

Reference