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Statistic
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Details for phenotype: Primary Hyperaldosteronism
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EndoNet ID: ENP00481
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Name
Primary Hyperaldosteronism
General information
This phenotype is pathologic
Primary aldosteronism implies an excessive organ damage to the heart, vessels and kidney, which translates into an excess of cardiovascular events.
[1]
Links to other resources
GO
regulation of aldosterone biosynthetic process
Medline Plus
000330
MeSH term
D006929
Disease database
3073
Phenotype triggers
more activity (high ligand concentration, overexpression) of
mineralcorticoid receptor
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in
kidney
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Primary aldosteronism, the most common form of endocrine hypertension is characterized by autonomous aldosterone production by the adrenal cortex (unilateral disease caused by aldosterone-producing adenoma and less frequently by unilateral adrenal hyperplasia; bilateral disease caused by idiopathic adrenal hyperplasia) resulting in hypertension with suppressed plasma renin, and, less frequently, in hypokalemia.
[1]
Reference