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Statistic
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Details for phenotype: carcinoid syndrome
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EndoNet ID: ENP00511
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Name
carcinoid syndrome
General information
This phenotype is pathologic
Links to other resources
GO
serotonin biosynthetic process
Medline Plus
000347
Disease database
2040
Phenotype triggers
more activity (high ligand concentration, overexpression) of
5-HT-2B
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in
vascularendothelial_cell
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Carcinoid tumors are characterized by their production of hormonal substances such as 5-hydroxytryptamine. The pathogenesis of the cardiac lesions and the bronchoconstriction is unknown, but the former probably involves activation of serotonin 5-HT2B receptors by serotonin.
[1]
Reference
